Mahalla al-Kubra is a large agricultural and industrial city in Egypt, located in the middle of the Nile Delta on the Western bank of the Damietta branch. It is famous for its dominant textile industry. It is the largest city of the Gharbia Governorate, with an estimated population of 500,000 inhabitants according to the 2001 census.

Mahalla al-Kubra is home to the largest Egyptian textile company, the Misr Spinning and Weaving Company, which employs approximately 27,000 people.